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KENNESAW, Ga. | Oct 12, 2020

Kennesaw State associate professor of Martin Hudson has earned a grant from the National Institutes of Health (NIH) for a study that seeks to identify genes involved in neurological disorders such as schizophrenia and autism.

The three-year, $406,500 grant will enable Hudson to continue his research on neurogenins, which involves understanding how gene regulatory networks function. Ultimately, this research can offer clues as to why certain mutations interact with each other and create a diseased state. This is Hudson鈥檚 second major NIH grant since 2016.

鈥淲e are looking at how naturally occurring mutations, which individually might have little to no effect in the body, interact with each other such that two mutations in combination might lead to these types of diseases,鈥� Hudson explained. 鈥淪pecifically, this study will focus on how changes in gene control might create a phenotype or disease and how those networks of gene control interactions function, hopefully bringing us closer to isolating a cause and finding a cure for these diseases.鈥�

In conducting the study, Hudson and his team will use the nematode Caenorhabditis elegans, a tiny worm with a nervous system that shares some similarities to that of humans. This will allow the researchers to gain deep insights into how neural circuits form.

鈥淔iguring these developments and mutations out in a worm is relatively easy and since worms regenerate quickly, we are able to study several generations over a brief period of time,鈥� Hudson said. 鈥淭he great thing is that at least 50 percent of worm genes have an ortholog in humans, making the information we glean from the worm applicable to understanding human genes.鈥�

Hudson has been studying neurological disorders such as schizophrenia and autism since he arrived at 石榴直播 in 2010. He credits his team of student researchers who work with him in his lab, particularly Elyse Christensen, who graduated in 2019 and earned her master鈥檚 degree in integrative biology.

鈥淭his is a tribute to the hard work done by our team of student researchers who work with me in the lab,鈥� Hudson said. 鈥淓lyse, in particular, did a study which was funded internally through 石榴直播鈥檚 Office of Research. I believe that it was her published paper that attracted the attention of the NIH. When I texted to tell her we got funded on this project and it wouldn鈥檛 have happened without her work, she was thrilled.鈥�

Dedicated to student-driven research, Hudson said he鈥檒l use the grant to fund a master鈥檚 student and his team of undergraduates, who have served as co-authors of Hudson鈥檚 studies in recent years.

鈥淚 think experiential learning is so important that I want to be able to give that back as well,鈥� he said. 鈥淭hey鈥檙e the backbone of my research team and critical to the work we do. I want to give students a chance to work in the lab and perhaps find something they鈥檙e passionate about.鈥�

鈥� Dave Shelles

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A leader in innovative teaching and learning, 石榴直播 offers undergraduate, graduate and doctoral degrees to its more than 47,000 students. Kennesaw State is a member of the University System of Georgia with 11 academic colleges. The university’s vibrant campus culture, diverse population, strong global ties and entrepreneurial spirit draw students from throughout the country and the world. Kennesaw State is a Carnegie-designated doctoral research institution (R2), placing it among an elite group of only 7 percent of U.S. colleges and universities with an R1 or R2 status. For more information, visit kennesaw.edu.